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Nat Faxon
Captain Underpants / Mr. Krupp (voice)
Jay Gragnani
Harold (voice)
Ramone Hamilton
George (voice)
Sean Astin
Narrator (voice)
Dayci Brookshire
Jessica / Dressy (voice)
Jim Cummings
Santa (voice)
Jorge Diaz
Melvin / Stanley Peet (voice)
Peter Hastings
Comic Narrator (voice)
Evan Kishiyama
Steve 'Gooch' Yamaguchi (voice)
David Koechner
Mr. Meaner (voice)
Erica Luttrell
Erica / George's Mom (voice)
Patty Mattson
Miss Anthrope / Harold's Mom (voice)