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When Anspaugh decides to retire as chief of staff and return to surgery, he appoints Romano as his replacement. Greene expresses reservations about the decision, but Weaver does not support Greene. Romano makes Weaver the new chief of emergency medicine.

After his mother's funeral, Dr. Greene comforts his father in San Diego. In Chicago, Romano surprises Corday by appointing her associate chief of surgery. Corday treats Elaine, Carter's lover, for breast cancer.

A recommendation from Weaver allows Jeanie to have temporary approval as a foster parent for baby Carlos. Reggie and Jeanie get married. Lucy and Kovac talk with a young woman whose husband they believe is very dangerous.

Hathaway befriends an out-of-work waitress, Meg. Seven-months pregnant, Meg cannot afford prenatal care. Hathaway invites her to the hospital, performs free tests and helps her interview for a job in the cafeteria.

A prank in a high school science class goes terribly awry, injuring a teacher and several students. Hathaway discovers Meg's drug addiction. Weaver and Greene notice Lawrence gets easily confused.

Benton struggles with the idea of taking a DNA test to determine whether or not Reese is actually his son. As the signs continue to pile up, Kerry and Mark use a fake patient to convince Dr. Lawrence of his Alzheimer's. Carter has trouble persuading a woman from a nursing home fire to sign a DNR for her husband and later is asked to forge charts for a family with no insurance. Carol continues to meddle in Meg's life, having her arrested so that she can be detoxed. Cleo is blamed for an explosion in the suture room but it may actually be Dr. Dave's fault.